SYRE
Spyre Therapeutics Inc
$107.43
▼ 0.4%Updated Today 11:10 AM ET
SYRE at a glance — five pillars scored 0–100 from real filed financials.
Overall: Unrated · 0/100. A wider, greener shape means more pillars look healthy. Dividends scores 0 when a company pays none — that is a choice, not a flaw.
Market Cap
$0.00
P/E
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Forward P/E (est.)
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ROE
—
Revenue Growth
—
EPS Growth
—
Profit Margin
—
FCF Yield
—
Debt / Equity
—
ROIC
-15.0%
Interest Coverage
—
Current Ratio
18.53x
Dividend Yield
—
Implied Growth (rev. DCF)
—
Rating Score
0/100
Spyre Therapeutics Inc (SYRE) is a small-cap company in the Biotechnology industry, part of the Health Care sector of the S&P 500.
Our model rates SYRE Unrated (0/100) on growth, profitability, financial health, and valuation. The summary below is built from its filed financials and current ratios and refreshes automatically.
Evidence of durable competitive advantage in the filed financials (10 years of history).
The numbers don't show a durable competitive advantage — margins, growth, or returns on capital have been unstable or thin. Great returns are still possible; they just aren't protected.
-10446.2% average over the last 3 years
±9797.7 pts around -5585.5% across 6 years
grew in 2 of the last 9 year-over-year periods
positive in 0 of 10 years
-15.0% latest fiscal year
A moat can't be proven by numbers alone — this scores the evidence a durable advantage leaves behind (pricing power, consistency, returns on capital), computed the same way for every stock. Pair it with the business overview before concluding anything.
Gross Margin
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Operating Margin
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Net Margin
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ROE
—
Total Debt
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Net Debt
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Net Debt / EBITDA
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Debt / Equity
—
Leverage: debt-to-equity is n/a, with a current ratio of 18.5x. Detailed balance-sheet leverage is limited for this name.
Operating CF
-$169.25M
Free Cash Flow
-$169.25M
FCF Margin
—
In the latest year Spyre Therapeutics Inc produced about -$169.25M of operating cash flow but negative free cash flow as it invested heavily. Cash flow is what ultimately pays shareholders, so it is worth tracking over time.
P/E
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P/S
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P/B
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EV / EBITDA
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SYRE trades at n/a trailing earnings. With no positive trailing earnings, value it on sales, cash flow, or growth rather than P/E.
Where SYRE sits versus its Health Care sector peers in the S&P 500.
Bands show the middle half (25th–75th percentile) of the 83 Health Care companies in the S&P 500 — the peer-relative anchor professional comps analysis uses. Context only — not investment advice.
How SYRE stacks up against its Health Care peers — valuation, profitability, and growth versus the sector median.
In the Health Care sector (324 S&P 500 companies), SYRE ranks #295 of 324 by our overall rating.
P/E vs sector
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median 27.3x
ROE vs sector
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median 14.1%
Growth vs sector
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median 7.6%
Sector rank
#295
of 324 by rating
Peers are the closest Health Care companies by sub-industry and size. Sector median is across all 324 S&P 500 names in the sector. Educational, not a recommendation.
The case for SYRE:
- As an established S&P 500 member in Health Care, it brings scale and a long operating history.
The case against SYRE:
- Like any single stock, it is exposed to competition, the economic cycle, and shifts in its end markets.
Market risk — sector rotation, the economic cycle, and broad sentiment move the stock regardless of fundamentals.
On balance, the picture is mixed: Spyre Therapeutics Inc is a small-cap health care business growing at a mature pace, with modest profitability, and a heavier debt load to watch. It trades at n/a earnings, which our model scores Unrated (0/100). Weigh this against your own goals and time horizon — this is educational information, not a recommendation.
Analyst Ratings
What 23 Wall Street analysts covering SYRE recommend (August 2026). Consensus is a useful sanity check — not a substitute for your own homework.
Analysts have turned more cautious over the last three months (-4 pts of buy ratings).
Latest SEC Filings
SYRE's most recent filings, straight from SEC EDGAR. Annual and quarterly reports are the deep dives; 8-Ks flag material events the moment they happen.
SYRE — frequently asked questions
Is SYRE a good stock to buy?
We don't give buy or sell advice. Review Spyre Therapeutics Inc's fundamentals, valuation, and 5-year financials on this page, then make your own decision — and consider a licensed professional.
Where does SYRE's data come from?
Live price data plus real fundamentals and 5-year financials pulled directly from Spyre Therapeutics Inc's SEC filings — refreshed automatically, not hand-entered.
How is the 5-year projection for SYRE calculated?
It's a scenario model: it grows revenue at an assumed rate, applies a profit margin and a valuation multiple, and shows the resulting share-price range. The assumptions are yours to change — it's a tool for thinking, not a prediction.
Is this SYRE analysis financial advice?
No. Everything on this page is educational research, not financial advice or a recommendation to buy or sell SYRE. Always do your own research and consider a licensed professional.
Data notice. Fundamentals and financial statements are sourced from company filings (SEC EDGAR) and market-data providers; prices and market caps refresh on trading days and may be delayed. Ratings, projections, technical signals, and written summaries are model- or rule-generated for education and may simplify or lag the latest filings.
Not advice. Nothing on this page is investment advice or a recommendation to buy, hold, or sell any security. Do your own research and consult a licensed financial professional before investing.